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Quinine is approved for treatment of malaria, but is also commonly prescribed to treat leg cramps and similar conditions. “We believe unapproved quinine products represent a serious health risk because of the widespread use of this product for treating leg cramps. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, fibrates, ginseng); stimulating insulin secretion (salicylates, NSAIDs, disopyramide, quinine, quinidine, MAOIs, ginseng); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). Although increased teratogenic risk has not been proven, avoiding quinine use during pregnancy has been recommended. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, quinine, quinidine, MAOIs, ginseng); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). The rate of spontaneous abortion was lower in women treated with quinine (3. quinine food/lifestyle InteractionsThere is 1 food/lifestyle interaction with quinineSee also. Quinine is considered compatible with breast-feeding by the American Academy of Pediatrics. Quinine is a drug with a narrow margin between an effective dose and a toxic dose. In doses several times higher than those used to treat malaria, quinine may stimulate the pregnant uterus. Quinine needs to be dosed carefully, and FDA-approved labeling reflects the fact that the risks associated with the use of this drug for treatment of leg cramps outweigh the benefits. I drink a glass of club soda with quinine in it. The development of more effective alternatives such as quinacrine, chloroquine, and primaquine in the twentieth century reduced the reliance on quinine. However, there is only one quinine product approved by the FDA. , sulfonylureas, meglitinides) may be potentiated by certain drugs, including ACE inhibitors, amylin analogs, anabolic steroids, fibrates, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, selective serotonin reuptake inhibitors (SSRIs), sulfonamides, disopyramide, propoxyphene, quinine, quinidine, and ginseng. A manufacturer of a formerly available quinine product considered it contraindicated in pregnancy. Quinine drugs are associated with serious side effects, such as cardiac arrhythmias, thrombocytopenia (a decrease in blood platelets that can cause hemorrhage or clotting problems), and severe hypersensitivity reactions. 6 mg/L and the ratio of cord plasma to maternal plasma quinine levels averaged 0. Quinine is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk. The quinine is known to stop muscle cramping and it has stopped my muscle cramps/spasms, and it might help you. Quinine was used starting in the 17th century as a prophylactic against malaria. The overall rate of congenital malformations was not different for women treated with quinine (1. Unlike the approved product, many unapproved quinine drug products are marketed without labeling cautioning against use of the product for treatment of leg cramps. There is also the potential for serious interactions between quinine drugs and other drugs, and there are conditions under which quinine should not be used. Because malaria is life-threatening, the risks associated with quinine use are justified for that condition.

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