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HepaticIn cases of amoxicillin-clavulanate-induced hepatotoxicity, biopsy findings have typically revealed evidence of cholestatic injury. This rash is not necessarily indicative of a lifelong amoxicillin hypersensitivity. You will need to discuss the benefits and risks of using Amoxicillin while you are pregnant. The bleeding was felt due to vitamin K deficiency as a result of depletion of intrinsic vitamin K-producing gut flora from use of amoxicillin for prophylaxis of subacute bacterial endocarditis. If you are or will be breast-feeding while you use Amoxicillin , check with your doctor. Amoxicillin rashes occur more frequently in patients with unrecognized infectious mononucleosis. Hypersensitivity reactions to amoxicillin are more likely in patients with a history of allergy, asthma, hay fever, or urticaria. No treatment-emergent adverse events were observed at significantly higher rates with amoxicillin three times daily plus lansoprazole three times daily dual therapy than with lansoprazole alone. Three out of four patients with infectious mononucleosis and an amoxicillin-associated rash displayed hypersensitivity to amoxicillin and ampicillin by skin tests and lymphocyte transformation tests. Keep Amoxicillin out of the reach of children and away from pets. Urticarial rash, erythematous maculopapular rash, edema, hypotension, fever, eosinophilia, and dyspnea have been associated with hypersensitivity reactions to amoxicillin. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving amoxicillin and clavulanate combination. Ask your health care provider if Amoxicillin may interact with other medicines that you take. Colitis and Clostridium difficile pseudomembranous colitis have been reported with amoxicillin. Elderly patients may be at increased risk of developing amoxicillin-clavulanate-induced jaundice. Am J Clin Path 45:493, 1966) utilized 30 mcg Augmentin™ discs for estimating the susceptibility of bacteria to amoxicillin/clavulanic acid tablets. Hypersensitivity may play a role in some cases of amoxicillin-clavulanate-induced renal and hepatic toxicity. Amoxicillin/clavulanate has been shown to have a wide range of activity which embraces β-lactamase-producing strains of both gram-positive and gram-negative aerobes, facultative anaerobes, and obligate anaerobes. Most of the amoxicillin is excreted unchanged in the urine. Rare cases of psychosis associated with amoxicillin therapy have been reported but may have been due to underlying infection or concomitant medication. Erythematous maculopapular rashes occur frequently in patients with infectious mononucleosis who take amoxicillin; these may be due to hypersensitivity.

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